The Agilent 8800 ICP-QQQ is the world’s first triple quadrupole ICP-MS — a truly ground-breaking instrument that transforms the ICP-MS landscape.
The 8800 ICP-QQQ combines the proven matrix tolerance and dynamic range capabilities of the 7700 Series ICP-MS with the incomparable power of MS/MS for interference removal. The result is a unique analytical tool that can handle even the most difficult samples and applications with ease.
8800 ICP-QQQ technical and performance highlights include:
• Unique tandem mass spectrometer configuration
• Innovative MS/MS mode for unprecedented interference removal in the collision/reaction cell
• Optimized vacuum system gives higher signal to noise than conventional quadrupole ICP-MS
• The highest abundance sensitivity ever seen in ICP-MS (theoretically <10-14)
• Many critical hardware components and ICP-MS MassHunter software platform shared with the proven 7700 Series ICP-MS
Agilent 8800 ICP-QQQ overview
ICP-QQQ: redefining ICP-MS performance
The revolutionary Agilent 8800 Triple Quadrupole ICP-MS (ICP-QQQ) combines the proven capabilities of the 7700 Series quadrupole ICP-MS (ICP-QMS) with the unique performance of MS/MS, only possible on a true tandem MS instrument.
The term “triple quadrupole” is used in organic mass spectrometry to describe instruments with two separate quadrupole mass fi lters in series, separated by a
chamber (or cell) housing an ion guide, where collision and reaction processes take place.
The collision/reaction cell may contain one of several different types of ion guide (quadrupole, hexapole, or octopole), but according to convention, instruments that contain any of these ion guides are commonly referred to as “triple quadrupole” mass spectrometers. The key aspect of the triple quadrupole confi guration is that all such instruments possess two separate mass filters, one before and one after the collision/reaction cell. In ICP-MS, this configuration is unique to the 8800 ICPQQQ.
The triple quad configuration of the Agilent 8800 ICP-QQQ offers fundamentally improved performance for interference removal in the collision/reaction cell, particularly in reaction mode.
Collision mode in ICP-QMS (using He cell gas) is effective in removing polyatomic interferences in high matrix samples. However He mode cannot provide complete removal of intense interferences on some key analytes such as P, S and Se, or enable ppt-level analysis in high-purity materials. For high-purity materials analysis using ICP-QMS, reaction mode (using a reactive cell gas) can be more effective than He mode for certain analytes.
But reaction mode on ICP-QMS often gives erratic results due to the inability to reject non-target ions prior to the cell. This leads to the formation of unpredictable, sample-dependent product ions from the variable reaction processes in the cell, especially when matrices are complex or variable. The Agilent 8800 ICP-QQQ solves these problems, enabling reaction mode to be used to its full potential.
